It is a famous result of Hilden and Montesinos that every closed orientable three-manifold can be realized as an irregular three-fold cover of S^3 branched over a knot. In contrast, a smooth four-manifold which can be realized as a cover of S^4 branched over a smooth surface must have signature equal to zero. Given two simply-connected, closed, oriented four- manifolds X and Y and a surface B embedded in X with an isolated singularity, I will prove a necessary condition for the existence of an irregular dihedral branched covering map f: Y -> X with branching set B. Conversely, given a simply-connected oriented closed four-manifold X, I will outline a construction realizing as irregular dihedral covers of X infinitely many (and possibly all) of the manifolds Y afforded by the necessary condition.