We study the parity of 2-Selmer ranks in the family of quadratic twists of a fixed principally polarised abelian variety over a number field. Specifically, we prove results about the proportion of twists having odd (resp. even) 2-Selmer rank. This generalises work of Klagsbrun–Mazur– Rubin for elliptic curves and Yu for Jacobians of hyperelliptic curves. Several differences in the statistics arise due to the possibility that the Shafarevich–Tate group (if finite) may have order twice a square.