Non-positively curved cube complexes arise in an impressive number of applied and theoretical settings, including configurations on graphs and right-angled Artin groups. The topology at infinity for an unbounded, locally finite complex is the topology that persists in the complement of any finite sub-complex. For example, a graph is one-ended if there is a single connected, unbounded component in the complement of any finite sub-graph. I will survey joint work with Jon McCammond and Noel Brady on local-to-asymptotic results for non-positively curved cube complexes, and explain in some detail joint work with Liang Zhang in the case of configurations on a complete graph.