Diffeomorphometry, Geodesic Positioning and High Throughput Neuroinformatics

We review progress in diffeomorphometry, the metric space construction for studying human anatomical shape. Within this setting geodesic positioning and geodesic coordinates play a central roll describing positioning of information across anatomical coordinate systems. Geodesic positioning systems play a central role in automated analyses of MR imagery, by transferring ontological atlas descriptions to targets for semantic labeling. We review several applications in neurodegenerative disorders including Alzheimer's and Huntington's diseases.